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Rubin R. Uncovering a link between the appendix and Parkinson disease risk
Journal of the American Medical Association (JAMA)
3 de julio 2019
página(s) 1

But recent studies suggest that the often-overlooked organ plays a role in determining whether its owner will someday be diagnosed with Parkinson disease (PD). Its exact role isn’t yet clear because findings have been conflicting. One study linked removal of the appendix to a lower risk of PD, while the other linked removal to a higher risk.

However, both studies implicate the protein a-synuclein, large aggregates of which form Lewy bodies—abnormal deposits in dopamine-producing neurons in the brains of people with PD. While Lewy bodies are a hallmark of PD, whether they cause the disease is not yet clear.

Studies suggest normal a-synuclein is involved in neurotransmission. The protein is also found in the gastrointestinal tract, which is why scientists have looked for a connection between the appendix and PD.